Analysis
Nature Aging maps three distinct tissue aging schedules without training on age
A new unsupervised method called PathStAR reveals that tissues age on distinct, nonlinear schedules rather than in sync. Applied to 25,306 post-mortem biopsies from 40 tissues across 970 donors, the model discovered three aging programs—early vascular, late reproductive, and biphasic digestive—without ever being trained to predict age itself.
